Dr. Pierre Kory Testifies at Senate Homeland Security Hearing on COV Treatments
Dr. Pierre Kory Testifies at Senate Homeland Security Hearing on COV Treatments
I DO NOT ADVISE ANYONE TO TAKE ANYTHING BEFORE EXTENSIVE REASERCH IS DONE.
Mass treatment with ivermectin
https://www.who.int/bulletin/volumes/82/8/562.pdf
Ivermectin
https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/
A five-day course of ivermectin for the treatment of COV
https://pubmed.ncbi.nlm.nih.gov/33278625/
Mechanistic insights into the inhibitory activity of FDA approved ivermectin against SARS-CoV-2: old drug with new implications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108190/
Ivermectin in the treatment of COV protocol for a systematic review and meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450968/
Safety of high-dose ivermectin: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/31960060/
Who’s Afraid Of Ivermectin?
https://www.acsh.org/news/2021/05/04/who%E2%80%99s-afraid-ivermectin-15529
The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
https://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c
the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
https://www.nature.com/articles/s42003-020-01577-x.pdf
as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.
Development, validation, and approval of COV specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COV drugs: designing, docking and molecular dynamics simulation study
https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g
From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373590/
Ritonavir, C37H48N6O5S2
Ivermectin, C48H74O14
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
Risk of virus developing resistance to PF-07321332
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full
With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.
In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor
Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)
The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions
Binding Interactions of Selected Drugs With Human ACE-2 Protein
that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions
With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein
With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions
Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions
Original link by Bloomberg Quicktake
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